Quantitative neuroanatomy for connectomics in Drosophila
نویسندگان
چکیده
منابع مشابه
Quantitative neuroanatomy for connectomics in Drosophila
Neuronal circuit mapping using electron microscopy demands laborious proofreading or reconciliation of multiple independent reconstructions. Here, we describe new methods to apply quantitative arbor and network context to iteratively proofread and reconstruct circuits and create anatomically enriched wiring diagrams. We measured the morphological underpinnings of connectivity in new and existin...
متن کاملTools for neuroanatomy and neurogenetics in Drosophila.
We demonstrate the feasibility of generating thousands of transgenic Drosophila melanogaster lines in which the expression of an exogenous gene is reproducibly directed to distinct small subsets of cells in the adult brain. We expect the expression patterns produced by the collection of 5,000 lines that we are currently generating to encompass all neurons in the brain in a variety of intersecti...
متن کاملEditorial: Quantitative Analysis of Neuroanatomy
Department of Informatics, School of Engineering and Informatics, University of Sussex, Brighton, UK, 2 Ernst Strüngmann Institute for Neuroscience in Cooperation with Max Planck Society, Frankfurt/Main, Germany, 3 Frankfurt Institute for Advanced Studies, Frankfurt/Main, Germany, Department of Applied Mathematics and Theoretical Physics, Cambridge Computational Biology Institute, University of...
متن کاملConnectomics-Based Analysis of Information Flow in the Drosophila Brain
Understanding the overall patterns of information flow within the brain has become a major goal of neuroscience. In the current study, we produced a first draft of the Drosophila connectome at the mesoscopic scale, reconstructed from 12,995 images of neuron projections collected in FlyCircuit (version 1.1). Neuron polarities were predicted according to morphological criteria, with nodes of the ...
متن کاملFunctional neuroanatomy of Drosophila olfactory memory formation.
New approaches, techniques and tools invented over the last decade and a half have revolutionized the functional dissection of neural circuitry underlying Drosophila learning. The new methodologies have been used aggressively by researchers attempting to answer three critical questions about olfactory memories formed with appetitive and aversive reinforcers: (1) Which neurons within the olfacto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.12059